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7068 matches
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organism
protein
1)
Homo sapiens
IRGM - Immunity-related GTPase family M protein; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune
response
probably
through
regulation
of autophagy. May
regulate
proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
[a.k.a. H0YBM2, IRGM1, ENSG00000237693]
2)
Homo sapiens
TSPYL5 - Testis-specific Y-encoded-like protein 5; Involved in modulation of cell growth and cellular
response
to gamma radiation
probably
via
regulation
of the Akt signaling pathway. Involved in
regulation
of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.
[a.k.a. KIAA1750, AB051537, NP_277047.2]
3)
Homo sapiens
LRRFIP1 - Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may
regulate
expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively
regulates
Toll-like receptor (TLR) signaling in
response
to agonist
probably
by competing with the negative FLII
regulator
for MYD88-binding.
[a.k.a. CCDS2521.1, ENST00000289175, XM_017005261.2]
4)
Homo sapiens
LRRFIP2 - Leucine-rich repeat flightless-interacting protein 2; May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively
regulates
Toll-like receptor (TLR) signaling in
response
to agonist
probably
by competing with the negative FLII
regulator
for MYD88-binding; Belongs to the LRRFIP family.
[a.k.a. UPI00017A8139, NP_001335237.1, XM_024453821]
5)
Homo sapiens
GSDME - Gasdermin-E, C-terminal; Plays a role in the TP53-
regulated
cellular
response
to DNA damage
probably
by cooperating with TP53.
[a.k.a. XP_016867291.1, GSDME-212, AAB83938.1]
6)
Homo sapiens
USP8 - Ubiquitin carboxyl-terminal hydrolase 8; Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in
response
to serum stimulation. May
regulate
T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1.
Probably
regulates
the stability of STAM2 and RASGRF1.
Regulates
endoso [...]
[a.k.a. UPI00022F8549, R-HSA-6807004, ENSP00000302239]
7)
Homo sapiens
CLEC10A - C-type lectin domain family 10 member A;
Probable
role in
regulating
adaptive and innate immune
responses
. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
[a.k.a. ENST00000254868, CLEC10A-204, hsa:10462]
8)
Homo sapiens
CREBL2 - cAMP-
responsive
element-binding protein-like 2;
Probable
regulator
of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily.
[a.k.a. BC112157, NM_001310, ENSP00000228865]
9)
Homo sapiens
SOS1 - Son of sevenless homolog 1; Promotes the exchange of Ras-bound GDP by GTP.
Probably
by promoting Ras activation,
regulates
phosphorylation of MAP kinase MAPK3 in
response
to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).
[a.k.a. R-HSA-9026519, NP_005624, R-HSA-388396]
10)
Homo sapiens
MAPKAP1 - Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which
regulates
cell growth and survival in
response
to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to
regulate
the actin cytoskeleton,
probably
by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...]
[a.k.a. NM_001006617, SIN1, R-HSA-9006925]
11)
Homo sapiens
RICTOR - Rapamycin-insensitive companion of mTOR; Subunit of mTORC2, which
regulates
cell growth and survival in
response
to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to
regulate
the actin cytoskeleton,
probably
by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activa [...]
[a.k.a. XM_011514005.2, ENST00000357387, NP_001272369]
12)
Homo sapiens
PRR5 - Proline-rich protein 5; Subunit of mTORC2, which
regulates
cell growth and survival in
response
to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to
regulate
the actin cytoskeleton,
probably
by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 [...]
[a.k.a. ENST00000492289, ENST00000431834, PRR5-206]
13)
Homo sapiens
MCOLN2 - Mucolipin-2; Nonselective cation channel
probably
playing a role in the
regulation
of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-
regulated
recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune
response
, may play a role in the
regulation
of chemokine se [...]
[a.k.a. R-HSA-3295583, 255231, AL358789]
14)
Homo sapiens
SPEN - Msx2-interacting protein; May serve as a nuclear matrix platform that organizes and integrates transcriptional
responses
. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2- mediated activation of the osteocalcin FGF-
responsive
element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which
probably
regulates
different key pathways such as the Notch pathway. Negative
regulator
of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses t [...]
[a.k.a. UPI000059CF6C, ENST00000673875, UPI000006FF0C]
15)
Homo sapiens
HABP4 - Intracellular hyaluronan-binding protein 4; RNA-binding protein that plays a role in the
regulation
of transcription, pre-mRNA splicing and mRNA translation. Negatively
regulates
DNA-binding activity of the transcription factor MEF2C in myocardial cells in
response
to mechanical stress (By similarity). Plays a role in pre-mRNA splicing
regulation
. Binds (via C-terminus) to poly(U) RNA. Involved in mRNA translation
regulation
,
probably
at the initiation step. Seems to play a role in PML-nuclear bodies formation.
[a.k.a. hyaluronan binding protein 4, ENSP00000364398, Hyaluronan binding protein 4]
16)
Homo sapiens
C17orf99 - Protein IL-40;
Probable
B cell-associated cytokine that plays a role in the
regulation
of humoral immune
responses
. Involved in lymphocyte B cell development and immunoglobulin/IgA production.
[a.k.a. UPI0005C12236, ENST00000586246.1, Chromosome 17 open reading frame 99]
17)
Homo sapiens
CCDC40 - Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are
responsible
for ciliary beat
regulation
, thereby playing a central role in motility in cilia and flagella.
Probably
acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39. Belongs to the CCDC40 family.
[a.k.a. NM_001243342, FAP172, coiled-coil domain containing 40]
18)
Homo sapiens
CCDC39 - Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are
responsible
for ciliary beat
regulation
, thereby playing a central role in motility in cilia and flagella.
Probably
acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly ; Belongs to the CCDC39 family.
[a.k.a. Q9UFE4, ENST00000651818, NP_852091]
19)
Homo sapiens
EIF5A2 - Eukaryotic translation initiation factor 5A-2; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover,
probably
acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and
probably
in a pathway involved in stress
response
and maintenance of cell wall integrity. Functions as a
regulator
of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By s [...]
[a.k.a. ENSG00000163577, UPI0000035FC3, NM_020390.5]
20)
Homo sapiens
EIF5AL1 - Eukaryotic translation initiation factor 5A-1-like; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover,
probably
acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and
probably
in a pathway involved in stress
response
and maintenance of cell wall integrity. Functions as a
regulator
of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation [...]
[a.k.a. BC070048, ENSP00000430706, NP_001093162.1]
7068 matches
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